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Adenosine-Dependent Activation Mechanism of Prodrugs Targeting an Aminoacyl-tRNA Synthetase
[Image: see text] Prodrugs have little or no pharmacological activity and are converted to active drugs in the body by enzymes, metabolic reactions, or through human-controlled actions. However, prodrugs promoting their chemical bioconversion without any of these processes have not been reported bef...
Autores principales: | Hoffmann, Guillaume, Le Gorrec, Madalen, Mestdach, Emeline, Cusack, Stephen, Salmon, Loïc, Jensen, Malene Ringkjøbing, Palencia, Andrés |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853866/ https://www.ncbi.nlm.nih.gov/pubmed/36599057 http://dx.doi.org/10.1021/jacs.2c04808 |
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