Improving spinosad production by tuning expressions of the forosamine methyltransferase and the forosaminyl transferase to reduce undesired less active byproducts in the heterologous host Streptomyces albus J1074

BACKGROUND: Spinosad is a macrolide insecticide with the tetracyclic lactone backbone to which forosamine and tri-o-methylrhamnose are attached. Both the sugar moieties are essential for its insecticidal activity. In biosynthesis of spinosad, the amino group of forosamine is dimethylated by SpnS and...

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Detalles Bibliográficos
Autores principales: Li, Xiaochen, Guo, Ruofei, Luan, Ji, Fu, Jun, Zhang, Youming, Wang, Hailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854174/
https://www.ncbi.nlm.nih.gov/pubmed/36658647
http://dx.doi.org/10.1186/s12934-023-02023-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854174/
https://www.ncbi.nlm.nih.gov/pubmed/36658647
http://dx.doi.org/10.1186/s12934-023-02023-3

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