Sequestration of Gβγ by deubiquitinated arrestins into the nucleus as a novel desensitization mechanism of G protein–coupled receptors

BACKGROUND: Desensitization of G protein–coupled receptors (GPCRs) refers to a rapid attenuation of responsiveness that occurs with repeated or continuous exposure to agonists. GRK-mediated phosphorylation and subsequent binding with arrestins in the activated receptor cytoplasmic cavity in competit...

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Detalles Bibliográficos
Autores principales: Min, Xiao, Sun, Ningning, Wang, Shujie, Zhang, Xiaohan, Kim, Kyeong-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854190/
https://www.ncbi.nlm.nih.gov/pubmed/36658650
http://dx.doi.org/10.1186/s12964-022-01013-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854190/
https://www.ncbi.nlm.nih.gov/pubmed/36658650
http://dx.doi.org/10.1186/s12964-022-01013-z

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