The Triterpenoid CDDO-Methyl Ester Redirects Macrophage Polarization and Reduces Lung Tumor Burden in a Nrf2-Dependent Manner

The NRF2/KEAP1 pathway protects healthy cells from malignant transformation and maintains cellular homeostasis. Up to 30% of human lung tumors gain constitutive NRF2 activity which contributes to cancer cell survival and chemoresistance, but the effects of NRF2 activation in immune cells within the...

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Detalles Bibliográficos
Autores principales: Moerland, Jessica A., Leal, Ana S., Lockwood, Beth, Demireva, Elena Y., Xie, Huirong, Krieger-Burke, Teresa, Liby, Karen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854457/
https://www.ncbi.nlm.nih.gov/pubmed/36670978
http://dx.doi.org/10.3390/antiox12010116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854457/
https://www.ncbi.nlm.nih.gov/pubmed/36670978
http://dx.doi.org/10.3390/antiox12010116

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