Tricyclic Fused Lactams by Mukaiyama Cyclisation of Phthalimides and Evaluation of their Biological Activity

We report that phthalimides may be cyclized using a Mukaiyama-type aldol coupling to give variously substituted fused lactam (1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-a]isoindol-5-one) systems. This novel process shows a high level of regioselectivity for o-substituted phthalimides, dictated by steric and...

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Detalles Bibliográficos
Autores principales: Ibbotson, Lewis T., Christensen, Kirsten E., Genov, Miroslav, Pretsch, Alexander, Pretsch, Dagmar, Moloney, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854654/
https://www.ncbi.nlm.nih.gov/pubmed/36671210
http://dx.doi.org/10.3390/antibiotics12010009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854654/
https://www.ncbi.nlm.nih.gov/pubmed/36671210
http://dx.doi.org/10.3390/antibiotics12010009

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