Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway

Hyperlipidemia results in endothelial dysfunction, which is intimately associated with disturbed mitochondrial homeostasis, and is a real risk factor for cardiovascular diseases (CVDs). Triphenylphosphonium (TPP(+))-HT, constructed by linking a mitochondrial-targeting moiety TPP(+) to hydroxytyrosol...

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Detalles Bibliográficos
Autores principales: Liu, Xuyun, Gao, Jing, Yan, Yizhen, Georgiou, Eleftheria A., Lou, Jing, Feng, Mengya, Zhang, Xing, Gao, Feng, Liu, Jiankang, Kostakis, Ioannis K., Zhao, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854738/
https://www.ncbi.nlm.nih.gov/pubmed/36671037
http://dx.doi.org/10.3390/antiox12010175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854738/
https://www.ncbi.nlm.nih.gov/pubmed/36671037
http://dx.doi.org/10.3390/antiox12010175

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