Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)

The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosomes and that of MRSA and various wild-type Gram nega...

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Detalles Bibliográficos
Autores principales: Lubriks, Dmitrijs, Haldimann, Klara, Hobbie, Sven N., Vasella, Andrea, Suna, Edgars, Crich, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854789/
https://www.ncbi.nlm.nih.gov/pubmed/36671225
http://dx.doi.org/10.3390/antibiotics12010025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854789/
https://www.ncbi.nlm.nih.gov/pubmed/36671225
http://dx.doi.org/10.3390/antibiotics12010025

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