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Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)

The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosomes and that of MRSA and various wild-type Gram nega...

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Detalles Bibliográficos
Autores principales:	Lubriks, Dmitrijs, Haldimann, Klara, Hobbie, Sven N., Vasella, Andrea, Suna, Edgars, Crich, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854789/ https://www.ncbi.nlm.nih.gov/pubmed/36671225 http://dx.doi.org/10.3390/antibiotics12010025

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