The Design, Synthesis, and Evaluation of Diaminopimelic Acid Derivatives as Potential dapF Inhibitors Preventing Lysine Biosynthesis for Antibacterial Activity

We created thiazole and oxazole analogues of diaminopimelic acid (DAP) by replacing its carboxyl groups and substituting sulphur for the central carbon atom. Toxicity, ADME, molecular docking, and in vitro antimicrobial studies of the synthesized compounds were carried out. These compounds displayed...

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Detalles Bibliográficos
Autores principales: Shaikh, Mohd Sayeed, Kale, Mayura A., Muralidharan, V., Venkatachalam, T., Ali, Syed Sarfaraz, Islam, Fahadul, Khan, Sharuk L., Siddiqui, Falak A., Urmee, Humaira, Tapadiya, Ganesh G., Dhawale, Sachin A., Ming, Long Chiau, Ibrahim, Ibrahim Abdel Aziz, Alzahrani, Abdullah R., Sarker, Md. Moklesur Rahman, Azlina, Mohd Fahami Nur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854792/
https://www.ncbi.nlm.nih.gov/pubmed/36671248
http://dx.doi.org/10.3390/antibiotics12010047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854792/
https://www.ncbi.nlm.nih.gov/pubmed/36671248
http://dx.doi.org/10.3390/antibiotics12010047

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