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Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer’s Disease-like Neuropathology in a Mouse Model for Down Syndrome

Down syndrome (DS) is the most frequent genetic cause of intellectual disability and is strongly associated with Alzheimer’s disease (AD). Brain insulin resistance greatly contributes to AD development in the general population and previous studies from our group showed an early accumulation of insu...

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Detalles Bibliográficos
Autores principales: Tramutola, Antonella, Lanzillotta, Simona, Aceto, Giuseppe, Pagnotta, Sara, Ruffolo, Gabriele, Cifelli, Pierangelo, Marini, Federico, Ripoli, Cristian, Palma, Eleonora, Grassi, Claudio, Di Domenico, Fabio, Perluigi, Marzia, Barone, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854894/
https://www.ncbi.nlm.nih.gov/pubmed/36670973
http://dx.doi.org/10.3390/antiox12010111