Cargando…

Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer’s Disease-like Neuropathology in a Mouse Model for Down Syndrome

Down syndrome (DS) is the most frequent genetic cause of intellectual disability and is strongly associated with Alzheimer’s disease (AD). Brain insulin resistance greatly contributes to AD development in the general population and previous studies from our group showed an early accumulation of insu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tramutola, Antonella, Lanzillotta, Simona, Aceto, Giuseppe, Pagnotta, Sara, Ruffolo, Gabriele, Cifelli, Pierangelo, Marini, Federico, Ripoli, Cristian, Palma, Eleonora, Grassi, Claudio, Di Domenico, Fabio, Perluigi, Marzia, Barone, Eugenio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854894/ https://www.ncbi.nlm.nih.gov/pubmed/36670973 http://dx.doi.org/10.3390/antiox12010111

Ejemplares similares

The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome
por: Zuliani, Ilaria, et al.
Publicado: (2020)

The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia
por: Perluigi, Marzia, et al.
Publicado: (2020)

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
por: Tramutola, Antonella, et al.
Publicado: (2018)

Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome
por: Di Domenico, Fabio, et al.
Publicado: (2019)

Proteomics Study of Peripheral Blood Mononuclear Cells in Down Syndrome Children
por: Lanzillotta, Chiara, et al.
Publicado: (2020)

It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease
por: Tramutola, Antonella, et al.
Publicado: (2016)

High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures
por: Zuliani, Ilaria, et al.
Publicado: (2021)

Classical and Unexpected Effects of Ultra-Micronized PEA in Neuromuscular Function
por: Cifelli, Pierangelo, et al.
Publicado: (2022)

GABAergic Neurotransmission in Human Tissues Is Modulated by Cannabidiol
por: Ruffolo, Gabriele, et al.
Publicado: (2022)

Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission?
por: Cifelli, Pierangelo, et al.
Publicado: (2020)

Dissecting the Molecular Determinants of GABA(A) Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy
por: Cifelli, Pierangelo, et al.
Publicado: (2021)

Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal‐derived extracellular vesicles
por: Perluigi, Marzia, et al.
Publicado: (2021)

BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration
por: Lanzillotta, Chiara, et al.
Publicado: (2020)

Effects of 3,4-diaminopyridine on myasthenia gravis: Preliminary results of an open-label study
por: Ceccanti, Marco, et al.
Publicado: (2022)

Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions
por: Dierssen, Mara, et al.
Publicado: (2020)

Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain
por: Di Domenico, Fabio, et al.
Publicado: (2013)

Unexpected Effect of IL-1β on the Function of GABA(A) Receptors in Pediatric Focal Cortical Dysplasia
por: Alfano, Veronica, et al.
Publicado: (2022)

Dynamic Changes of BVRA Protein Levels Occur in Response to Insulin: A Pilot Study in Humans
por: Cimini, Flavia Agata, et al.
Publicado: (2023)

Changes in the sensitivity of GABA(A) current rundown to drug treatments in a model of temporal lobe epilepsy
por: Cifelli, Pierangelo, et al.
Publicado: (2013)

Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression
por: Tramutola, Antonella, et al.
Publicado: (2020)

Cannabis in epilepsy: From clinical practice to basic research focusing on the possible role of cannabidivarin
por: Morano, Alessandra, et al.
Publicado: (2016)

Modulation of GABAergic dysfunction due to SCN1A mutation linked to Hippocampal Sclerosis
por: Ruffolo, Gabriele, et al.
Publicado: (2020)

GABA(A) receptor function is enhanced by Interleukin-10 in human epileptogenic gangliogliomas and its effect is counteracted by Interleukin-1β
por: Ruffolo, Gabriele, et al.
Publicado: (2022)

Role of Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update
por: Cimini, Flavia Agata, et al.
Publicado: (2022)

Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia
por: Perluigi, Marzia, et al.
Publicado: (2012)

GLUT-1 changes in paediatric Huntington disease brain cortex and fibroblasts: an observational case-control study
por: Tramutola, Antonella, et al.
Publicado: (2023)

Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity
por: Bouzidi, Amani, et al.
Publicado: (2020)

Human iPSC Modeling of Genetic Febrile Seizure Reveals Aberrant Molecular and Physiological Features Underlying an Impaired Neuronal Activity
por: Scalise, Stefania, et al.
Publicado: (2022)

Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice
por: Virlogeux, Amandine, et al.
Publicado: (2021)

Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects
por: Morano, Alessandra, et al.
Publicado: (2020)

Engineering memory with an extrinsically disordered kinase
por: Ripoli, Cristian, et al.
Publicado: (2023)

Neuromuscular magnetic stimulation counteracts muscle decline in ALS patients: results of a randomized, double-blind, controlled study
por: Musarò, Antonio, et al.
Publicado: (2019)

Intranasal epidermal growth factor treatment rescues neonatal brain injury
por: Scafidi, Joseph, et al.
Publicado: (2013)

Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency
por: Root, Jessica, et al.
Publicado: (2023)

Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models
por: Margotta, Cassandra, et al.
Publicado: (2023)

Intranasal Rapamycin Rescues Mice from Staphylococcal Enterotoxin B-Induced Shock
por: Krakauer, Teresa, et al.
Publicado: (2012)

Overcoming the challenges of developing an intranasal diazepam rescue therapy for the treatment of seizure clusters
por: Cloyd, James, et al.
Publicado: (2021)

Intranasal delivery of NGF rescues hearing impairment in aged SAMP8 mice
por: Castelli, Vanessa, et al.
Publicado: (2023)

Cerebral Organoids for Modeling of HSV-1-Induced-Amyloid β Associated Neuropathology and Phenotypic Rescue
por: Qiao, Haowen, et al.
Publicado: (2022)

Nano‐Brake Halts Mitochondrial Dysfunction Cascade to Alleviate Neuropathology and Rescue Alzheimer's Cognitive Deficits
por: Zhang, Qian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bpj0eu0gsahpiv7107ipeee0ec