Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions

New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerfu...

Descripción completa

Detalles Bibliográficos
Autores principales: Trejo, Angela, Masdeu, Carme, Serrano-Pérez, Irene, Pedrola, Marina, Juanola, Narcís, Ghashghaei, Ouldouz, Jiménez-Galisteo, Guadalupe, Lavilla, Rodolfo, Palacios, Francisco, Alonso, Concepción, Viñas, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854905/
https://www.ncbi.nlm.nih.gov/pubmed/36671284
http://dx.doi.org/10.3390/antibiotics12010083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854905/
https://www.ncbi.nlm.nih.gov/pubmed/36671284
http://dx.doi.org/10.3390/antibiotics12010083

Ejemplares similares