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Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions
New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerfu...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854905/ https://www.ncbi.nlm.nih.gov/pubmed/36671284 http://dx.doi.org/10.3390/antibiotics12010083 |
| _version_ | 1784873244297265152 |
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| author | Trejo, Angela Masdeu, Carme Serrano-Pérez, Irene Pedrola, Marina Juanola, Narcís Ghashghaei, Ouldouz Jiménez-Galisteo, Guadalupe Lavilla, Rodolfo Palacios, Francisco Alonso, Concepción Viñas, Miguel |
| author_facet | Trejo, Angela Masdeu, Carme Serrano-Pérez, Irene Pedrola, Marina Juanola, Narcís Ghashghaei, Ouldouz Jiménez-Galisteo, Guadalupe Lavilla, Rodolfo Palacios, Francisco Alonso, Concepción Viñas, Miguel |
| author_sort | Trejo, Angela |
| collection | PubMed |
| description | New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerful tool to design new and effective antimicrobials. In this case, the readily synthesized compounds open new possibilities in the search for antimicrobials active on mycolic acid-containing bacteria. |
| format | Online Article Text |
| id | pubmed-9854905 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-98549052023-01-21 Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions Trejo, Angela Masdeu, Carme Serrano-Pérez, Irene Pedrola, Marina Juanola, Narcís Ghashghaei, Ouldouz Jiménez-Galisteo, Guadalupe Lavilla, Rodolfo Palacios, Francisco Alonso, Concepción Viñas, Miguel Antibiotics (Basel) Article New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerful tool to design new and effective antimicrobials. In this case, the readily synthesized compounds open new possibilities in the search for antimicrobials active on mycolic acid-containing bacteria. MDPI 2023-01-03 /pmc/articles/PMC9854905/ /pubmed/36671284 http://dx.doi.org/10.3390/antibiotics12010083 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Trejo, Angela Masdeu, Carme Serrano-Pérez, Irene Pedrola, Marina Juanola, Narcís Ghashghaei, Ouldouz Jiménez-Galisteo, Guadalupe Lavilla, Rodolfo Palacios, Francisco Alonso, Concepción Viñas, Miguel Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions |
| title | Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions |
| title_full | Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions |
| title_fullStr | Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions |
| title_full_unstemmed | Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions |
| title_short | Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions |
| title_sort | efficient antimycolata agents by increasing the lipophilicity of known antibiotics through multicomponent reactions |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854905/ https://www.ncbi.nlm.nih.gov/pubmed/36671284 http://dx.doi.org/10.3390/antibiotics12010083 |
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