Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine

Fungal infections have become a growing public health challenge due to the clinical transmission of pathogenic fungi. The currently available antifungal drugs leave very limited choices for clinical physicians to deal with such situation, not to mention the long-standing problems of emerging drug re...

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Autores principales: Zhong, Hua, Han, Lei, Lu, Ren-Yi, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855100/
https://www.ncbi.nlm.nih.gov/pubmed/36671249
http://dx.doi.org/10.3390/antibiotics12010048
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author Zhong, Hua
Han, Lei
Lu, Ren-Yi
Wang, Yan
author_facet Zhong, Hua
Han, Lei
Lu, Ren-Yi
Wang, Yan
author_sort Zhong, Hua
collection PubMed
description Fungal infections have become a growing public health challenge due to the clinical transmission of pathogenic fungi. The currently available antifungal drugs leave very limited choices for clinical physicians to deal with such situation, not to mention the long-standing problems of emerging drug resistance, side effects and heavy economic burdens imposed to patients. Therefore, new antifungal drugs are urgently needed. Screening drugs from natural products and using synthetic biology strategies are very promising for antifungal drug development. Chinese medicine is a vast library of natural products of biologically active molecules. According to traditional Chinese medicine (TCM) theory, preparations used to treat fungal diseases usually have antifungal and immunomodulatory functions. This suggests that if antifungal drugs are used in combination with immunomodulatory drugs, better results may be achieved. Studies have shown that the active components of TCM have strong antifungal or immunomodulatory effects and have broad application prospects. In this paper, the latest research progress of antifungal and immunomodulatory components of TCM is reviewed and discussed, hoping to provide inspiration for the design of novel antifungal compounds and to open up new horizons for antifungal treatment strategies.
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spelling pubmed-98551002023-01-21 Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine Zhong, Hua Han, Lei Lu, Ren-Yi Wang, Yan Antibiotics (Basel) Review Fungal infections have become a growing public health challenge due to the clinical transmission of pathogenic fungi. The currently available antifungal drugs leave very limited choices for clinical physicians to deal with such situation, not to mention the long-standing problems of emerging drug resistance, side effects and heavy economic burdens imposed to patients. Therefore, new antifungal drugs are urgently needed. Screening drugs from natural products and using synthetic biology strategies are very promising for antifungal drug development. Chinese medicine is a vast library of natural products of biologically active molecules. According to traditional Chinese medicine (TCM) theory, preparations used to treat fungal diseases usually have antifungal and immunomodulatory functions. This suggests that if antifungal drugs are used in combination with immunomodulatory drugs, better results may be achieved. Studies have shown that the active components of TCM have strong antifungal or immunomodulatory effects and have broad application prospects. In this paper, the latest research progress of antifungal and immunomodulatory components of TCM is reviewed and discussed, hoping to provide inspiration for the design of novel antifungal compounds and to open up new horizons for antifungal treatment strategies. MDPI 2022-12-28 /pmc/articles/PMC9855100/ /pubmed/36671249 http://dx.doi.org/10.3390/antibiotics12010048 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhong, Hua
Han, Lei
Lu, Ren-Yi
Wang, Yan
Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine
title Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine
title_full Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine
title_fullStr Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine
title_full_unstemmed Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine
title_short Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine
title_sort antifungal and immunomodulatory ingredients from traditional chinese medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855100/
https://www.ncbi.nlm.nih.gov/pubmed/36671249
http://dx.doi.org/10.3390/antibiotics12010048
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