Mechanism by Which PF-3758309, a Pan Isoform Inhibitor of p21-Activated Kinases, Blocks Reactivation of HIV-1 Latency

The “block and lock” strategy is one approach that might elicit a sterilizing cure for HIV-1 infection. The “block” refers to a compound’s ability to inhibit latent HIV-1 proviral transcription, while the “lock” refers to its capacity to induce permanent proviral silencing. We previously identified...

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Detalles Bibliográficos
Autores principales: Vargas, Benni, Boslett, James, Yates, Nathan, Sluis-Cremer, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855626/
https://www.ncbi.nlm.nih.gov/pubmed/36671485
http://dx.doi.org/10.3390/biom13010100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855626/
https://www.ncbi.nlm.nih.gov/pubmed/36671485
http://dx.doi.org/10.3390/biom13010100

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