Understanding Calmodulin Variants Affecting Calcium-Dependent Inactivation of L-Type Calcium Channels through Whole-Cell Simulation of the Cardiac Ventricular Myocyte

Mutations in the calcium-sensing protein calmodulin (CaM) have been linked to two cardiac arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic Ventricular Tachycardia Type 4 (CPVT4), with varying degrees of severity. Functional characterization of the CaM mutants most s...

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Detalles Bibliográficos
Autores principales: McCoy, Matthew D., Ullah, Aman, Lederer, W. Jonathan, Jafri, M. Saleet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855640/
https://www.ncbi.nlm.nih.gov/pubmed/36671457
http://dx.doi.org/10.3390/biom13010072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855640/
https://www.ncbi.nlm.nih.gov/pubmed/36671457
http://dx.doi.org/10.3390/biom13010072

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