Genetic Ablation of the Nutrient Sensor Ogt in Endocrine Progenitors Is Dispensable for β-Cell Development but Essential for Maintenance of β-Cell Mass

Previously we utilized a murine model to demonstrate that Ogt deletion in pancreatic progenitors (OgtKO(Panc)) causes pancreatic hypoplasia, partly mediated by a reduction in the Pdx1-expressing pancreatic progenitor pool. Here, we continue to explore the role of Ogt in pancreas development by delet...

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Detalles Bibliográficos
Autores principales: Wong, Alicia, Akhaphong, Brian, Baumann, Daniel, Alejandro, Emilyn U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855876/
https://www.ncbi.nlm.nih.gov/pubmed/36672613
http://dx.doi.org/10.3390/biomedicines11010105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855876/
https://www.ncbi.nlm.nih.gov/pubmed/36672613
http://dx.doi.org/10.3390/biomedicines11010105

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