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Genetic Ablation of the Nutrient Sensor Ogt in Endocrine Progenitors Is Dispensable for β-Cell Development but Essential for Maintenance of β-Cell Mass
Previously we utilized a murine model to demonstrate that Ogt deletion in pancreatic progenitors (OgtKO(Panc)) causes pancreatic hypoplasia, partly mediated by a reduction in the Pdx1-expressing pancreatic progenitor pool. Here, we continue to explore the role of Ogt in pancreas development by delet...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855876/ https://www.ncbi.nlm.nih.gov/pubmed/36672613 http://dx.doi.org/10.3390/biomedicines11010105 |