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Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?
Leucine rich-repeat kinase 2 (LRRK2) is the most well-known etiologic gene for familial Parkinson’s disease (PD). Its gene product is a large kinase with multiple functional domains that phosphorylates a subset of Rab small GTPases. However, studies of autopsy cases with LRRK2 mutations indicate a v...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856048/ https://www.ncbi.nlm.nih.gov/pubmed/36671564 http://dx.doi.org/10.3390/biom13010178 |