Complexed Crystal Structure of the Dihydroorotase Domain of Human CAD Protein with the Anticancer Drug 5-Fluorouracil

Dihydroorotase (DHOase) is the third enzyme in the pathway used for the biosynthesis of pyrimidine nucleotides. In mammals, DHOase is active in a trifunctional enzyme, CAD, which also carries out the activities of carbamoyl phosphate synthetase and aspartate transcarbamoylase. Prior to this study, i...

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Detalles Bibliográficos
Autores principales: Lin, En-Shyh, Huang, Yen-Hua, Yang, Po-Chun, Peng, Wei-Feng, Huang, Cheng-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856072/
https://www.ncbi.nlm.nih.gov/pubmed/36671534
http://dx.doi.org/10.3390/biom13010149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856072/
https://www.ncbi.nlm.nih.gov/pubmed/36671534
http://dx.doi.org/10.3390/biom13010149

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