In Silico Structural Analysis Predicting the Pathogenicity of PLP1 Mutations in Multiple Sclerosis

The X chromosome gene PLP1 encodes myelin proteolipid protein (PLP), the most prevalent protein in the myelin sheath surrounding the central nervous system. X-linked dysmyelinating disorders such as Pelizaeus–Merzbacher disease (PMD) or spastic paraplegia type 2 (SPG2) are typically caused by point...

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Detalles Bibliográficos
Autores principales: Avramouli, Antigoni, Krokidis, Marios G., Exarchos, Themis P., Vlamos, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856082/
https://www.ncbi.nlm.nih.gov/pubmed/36672024
http://dx.doi.org/10.3390/brainsci13010042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856082/
https://www.ncbi.nlm.nih.gov/pubmed/36672024
http://dx.doi.org/10.3390/brainsci13010042

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