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Protein Conformational Dynamics Underlie Selective Recognition of Thermophilic over Mesophilic Enzyme I by a Substrate Analogue

Substrate selectivity is an important preventive measure to decrease the possibility of cross interactions between enzymes and metabolites that share structural similarities. In addition, understanding the mechanisms that determine selectivity towards a particular substrate increases the knowledge b...

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Detalles Bibliográficos
Autores principales: Singh, Aayushi, Burns, Daniel, Sedinkin, Sergey L., Van Veller, Brett, Potoyan, Davit A., Venditti, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856155/
https://www.ncbi.nlm.nih.gov/pubmed/36671545
http://dx.doi.org/10.3390/biom13010160