The Anti-Cancer Activity of Pentamidine and Its Derivatives (WLC-4059) Is through Blocking the Interaction between S100A1 and RAGE V Domain

The S100A1 protein in humans is a calcium-binding protein. Upon Ca(2+) binding to S100A1 EF-hand motifs, the conformation of S100A1 changes and promotes interactions with target proteins. RAGE consists of three domains: the cytoplasmic, transmembrane, and extracellular domains. The extracellular dom...

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Detalles Bibliográficos
Autores principales: Parveen, Nuzhat, Chiu, Wei-Jung, Shen, Li-Ching, Chou, Ruey-Hwang, Sun, Chung-Ming, Yu, Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856166/
https://www.ncbi.nlm.nih.gov/pubmed/36671465
http://dx.doi.org/10.3390/biom13010081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856166/
https://www.ncbi.nlm.nih.gov/pubmed/36671465
http://dx.doi.org/10.3390/biom13010081

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