A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing

CONTEXT: Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones into biologically active peptides. Somatic mutations of insulinomas are associated with genetic defects interfering with control of insulin secretion from pancreat...

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Detalles Bibliográficos
Autores principales: Avari, Parizad, Eng, Pei Chia, Hu, Ming, Chen, Runzhi, Popovic, Natalija, Polychronakos, Constantin, Spalding, Duncan, Rutter, Guy A, Oliver, Nick, Wernig, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Clinical Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856271/
https://www.ncbi.nlm.nih.gov/pubmed/36694809
http://dx.doi.org/10.1210/jendso/bvac196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856271/
https://www.ncbi.nlm.nih.gov/pubmed/36694809
http://dx.doi.org/10.1210/jendso/bvac196

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