Cargando…
A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing
CONTEXT: Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones into biologically active peptides. Somatic mutations of insulinomas are associated with genetic defects interfering with control of insulin secretion from pancreat...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856271/ https://www.ncbi.nlm.nih.gov/pubmed/36694809 http://dx.doi.org/10.1210/jendso/bvac196 |