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A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing

CONTEXT: Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones into biologically active peptides. Somatic mutations of insulinomas are associated with genetic defects interfering with control of insulin secretion from pancreat...

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Detalles Bibliográficos
Autores principales:	Avari, Parizad, Eng, Pei Chia, Hu, Ming, Chen, Runzhi, Popovic, Natalija, Polychronakos, Constantin, Spalding, Duncan, Rutter, Guy A, Oliver, Nick, Wernig, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Clinical Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856271/ https://www.ncbi.nlm.nih.gov/pubmed/36694809 http://dx.doi.org/10.1210/jendso/bvac196

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