Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability

SIMPLE SUMMARY: We have recently reported that the cytosolic C-terminal domain (CTD) of the tumour suppressor PTCH1, the Hedgehog proteins receptor, interacts with the autophagy-related protein ATG101 and impairs autophagic flux. In this study, we identified the interaction region and found that it...

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Detalles Bibliográficos
Autores principales: Caballero-Ruiz, Begoña, Gkotsi, Danai S., Ollerton, Hattie, Morales-Alcala, Cintli C., Bordone, Rosa, Jenkins, Georgia M. L., Di Magno, Laura, Canettieri, Gianluca, Riobo-Del Galdo, Natalia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856372/
https://www.ncbi.nlm.nih.gov/pubmed/36672319
http://dx.doi.org/10.3390/cancers15020369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856372/
https://www.ncbi.nlm.nih.gov/pubmed/36672319
http://dx.doi.org/10.3390/cancers15020369

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