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Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability

SIMPLE SUMMARY: We have recently reported that the cytosolic C-terminal domain (CTD) of the tumour suppressor PTCH1, the Hedgehog proteins receptor, interacts with the autophagy-related protein ATG101 and impairs autophagic flux. In this study, we identified the interaction region and found that it...

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Detalles Bibliográficos
Autores principales:	Caballero-Ruiz, Begoña, Gkotsi, Danai S., Ollerton, Hattie, Morales-Alcala, Cintli C., Bordone, Rosa, Jenkins, Georgia M. L., Di Magno, Laura, Canettieri, Gianluca, Riobo-Del Galdo, Natalia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856372/ https://www.ncbi.nlm.nih.gov/pubmed/36672319 http://dx.doi.org/10.3390/cancers15020369

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