Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions

The NLRP3 inflammasome is a multimolecular complex that processes inactive IL-1β and IL-18 into proinflammatory cytokines. OLT1177 is an orally active small compound that specifically inhibits NLRP3. Here, B16F10 melanoma were implanted in mice and treated with OLT1177 as well as combined with the g...

Descripción completa

Detalles Bibliográficos
Autores principales: Dinarello, Alberto, Mills, Taylor S., Tengesdal, Isak W., Powers, Nicholas E., Azam, Tania, Dinarello, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856388/
https://www.ncbi.nlm.nih.gov/pubmed/36672229
http://dx.doi.org/10.3390/cells12020294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856388/
https://www.ncbi.nlm.nih.gov/pubmed/36672229
http://dx.doi.org/10.3390/cells12020294

Ejemplares similares