Inhibition of PI3K Class IA Kinases Using GDC-0941 Overcomes Cytoprotection of Multiple Myeloma Cells in the Osteoclastic Bone Marrow Microenvironment Enhancing the Efficacy of Current Clinical Therapeutics

SIMPLE SUMMARY: The activation of osteoclasts occurs in up to 80% of myeloma patients. Osteoclasts promote myeloma resistance to therapeutic treatments and the formation of bone lytic lesions, resulting in bone pain and fractures in patients. However, the role of osteoclasts in drug resistance is ge...

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Detalles Bibliográficos
Autores principales: Kikuchi, Hugh, Amofa, Eunice, Mcenery, Maeve, Schey, Steve Arthur, Ramasamy, Karthik, Farzaneh, Farzin, Calle, Yolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856454/
https://www.ncbi.nlm.nih.gov/pubmed/36672411
http://dx.doi.org/10.3390/cancers15020462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856454/
https://www.ncbi.nlm.nih.gov/pubmed/36672411
http://dx.doi.org/10.3390/cancers15020462

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