The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons

Background: The N-methyl-D-aspartate receptor (NMDAR) is a target in current treatments for Alzheimer’s disease (AD). The human prion protein (PrPC) has an important role in the pathophysiology of AD. We hypothesized that PrPC modulates NMDA signaling, thus being a process associated with Alzheimer’...

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Detalles Bibliográficos
Autores principales: Rivas-Santisteban, Rafael, Raïch, Iu, Aguinaga, David, Saura, Carlos A., Franco, Rafael, Navarro, Gemma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856489/
https://www.ncbi.nlm.nih.gov/pubmed/36672218
http://dx.doi.org/10.3390/cells12020283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856489/
https://www.ncbi.nlm.nih.gov/pubmed/36672218
http://dx.doi.org/10.3390/cells12020283

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