Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease

The brief opening mode of the mitochondrial permeability transition pore (mPTP) serves as a calcium (Ca(2+)) release valve to prevent mitochondrial Ca(2+) (mCa(2+)) overload. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress-induced arrhythmic syndrome due to mutations in the...

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Detalles Bibliográficos
Autores principales: Deb, Arpita, Tow, Brian D., Qing, You, Walker, Madelyn, Hodges, Emmanuel R., Stewart, James A., Knollmann, Björn C., Zheng, Yi, Wang, Ying, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856515/
https://www.ncbi.nlm.nih.gov/pubmed/36672139
http://dx.doi.org/10.3390/cells12020204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856515/
https://www.ncbi.nlm.nih.gov/pubmed/36672139
http://dx.doi.org/10.3390/cells12020204

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