DHODH Inhibition Exerts Synergistic Therapeutic Effect with Cisplatin to Induce Ferroptosis in Cervical Cancer through Regulating mTOR Pathway

SIMPLE SUMMARY: Ferroptosis exhibits potent antitumor ability and dihydroorotate dehydrogenase (DHODH) has recently been identified as a novel ferroptosis defender independently of GPX4 or FSP1. DHODH has been studied in several diseases including oral squamous cell carcinoma and small cell lung can...

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Detalles Bibliográficos
Autores principales: Jiang, Mengying, Song, Yizuo, Liu, Hejing, Jin, Yanshan, Li, Ruyi, Zhu, Xueqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856746/
https://www.ncbi.nlm.nih.gov/pubmed/36672495
http://dx.doi.org/10.3390/cancers15020546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856746/
https://www.ncbi.nlm.nih.gov/pubmed/36672495
http://dx.doi.org/10.3390/cancers15020546

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