Cargando…

Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications

SIMPLE SUMMARY: Ewing sarcoma is a malignant pediatric bone cancer currently lacking targeted therapy. In the US there are ~200 patients diagnosed each year and relapse is associated with resistance to the standard-of-care chemotherapy. Thus, it remains an urgent unmet medical need to develop effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Le, Davis, Ian J., Liu, Pengda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857208/ https://www.ncbi.nlm.nih.gov/pubmed/36672331 http://dx.doi.org/10.3390/cancers15020382

Ejemplares similares

Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
por: García-Domínguez, Daniel J., et al.
Publicado: (2021)

High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma
por: Orth, Martin F., et al.
Publicado: (2020)

Mechanisms of SOD1 regulation by post-translational modifications
por: Banks, C.J., et al.
Publicado: (2019)

YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy
por: Yin, Qiyan, et al.
Publicado: (2022)

Functional Regulation of PPARs through Post-Translational Modifications
por: Brunmeir, Reinhard, et al.
Publicado: (2018)

Post-Transcriptional and Post-Translational Modifications in Telomerase Biogenesis and Recruitment to Telomeres
por: Shepelev, Nikita, et al.
Publicado: (2023)

Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways
por: Deng, Yu, et al.
Publicado: (2022)

Functional role of post-translational modifications of Sp1 in tumorigenesis
por: Chang, Wen-Chang, et al.
Publicado: (2012)

Epigenetic Regulation and Post-Translational Modifications of SNAI1 in Cancer Metastasis
por: Dong, Bo, et al.
Publicado: (2021)

Regulation of Deubiquitinating Enzymes by Post-Translational Modifications
por: Das, Tanuza, et al.
Publicado: (2020)

Regulation of Viral Restriction by Post-Translational Modifications
por: Chamontin, Célia, et al.
Publicado: (2021)

Targeting PTEN Regulation by Post Translational Modifications
por: González-García, Ana, et al.
Publicado: (2022)

Knockdown of EWSR1/FLI1 expression alters the transcriptome of Ewing sarcoma cells in vitro
por: Wang, Jihan, et al.
Publicado: (2016)

Post-Translational Modifications of the TAK1-TAB Complex
por: Hirata, Yusuke, et al.
Publicado: (2017)

The Transcription Factor FEZF1, a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes
por: García-García, Laura, et al.
Publicado: (2021)

Post-translational modifications as key regulators of TNF-induced necroptosis
por: Liu, X, et al.
Publicado: (2016)

Post-translational modifications of coronavirus proteins: roles and function
por: Fung, To Sing, et al.
Publicado: (2018)

How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance
por: Sales-Gil, Raquel, et al.
Publicado: (2020)

Regulating tumor suppressor genes: post-translational modifications
por: Chen, Ling, et al.
Publicado: (2020)

Post translational modification of Parkin
por: Chakraborty, Joy, et al.
Publicado: (2017)

Regulation of DELLA Proteins by Post-translational Modifications
por: Blanco-Touri��n, Noel, et al.
Publicado: (2020)

Post-Translational Modifications of Transcription Factors Harnessing the Etiology and Pathophysiology in Colonic Diseases
por: Hsu, Chao-Yuan, et al.
Publicado: (2020)

Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma
por: Yamamoto, Yoshinari, et al.
Publicado: (2015)

Regulation of p73 activity by post-translational modifications
por: Conforti, F, et al.
Publicado: (2012)

Post-translational modification-regulated leukocyte adhesion and migration
por: Loh, Jia Tong, et al.
Publicado: (2016)

Regulation of Protein Post-Translational Modifications on Metabolism of Actinomycetes
por: Sun, Chen-Fan, et al.
Publicado: (2020)

Multilevel Regulation of Peroxisomal Proteome by Post-Translational Modifications
por: Sandalio, Luisa M., et al.
Publicado: (2019)

Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications
por: Zenata, Ondrej, et al.
Publicado: (2017)

Therapeutic Potential of EWSR1–FLI1 Inactivation by CRISPR/Cas9 in Ewing Sarcoma
por: Cervera, Saint T., et al.
Publicado: (2021)

Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy
por: Park, Hyewon, et al.
Publicado: (2020)

Regulation of Intrinsic Functions of PD-L1 by Post-Translational Modification in Tumors
por: Nihira, Naoe Taira, et al.
Publicado: (2022)

Function of Centriolar Satellites and Regulation by Post-Translational Modifications
por: Renaud, Clotilde C. N., et al.
Publicado: (2021)

Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors
por: Cantile, Monica, et al.
Publicado: (2013)

Post-Translational Modification and Subcellular Distribution of Rac1: An Update
por: Abdrabou, Abdalla, et al.
Publicado: (2018)

Post-Translational Modifications of Circulating Alpha-1-Antitrypsin Protein
por: Lechowicz, Urszula, et al.
Publicado: (2020)

Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast
por: Batista-Nascimento, Liliana, et al.
Publicado: (2011)

Regulation of post-translational modification in breast cancer treatment
por: Heo, Kyung-Sun
Publicado: (2019)

Protein post-translational modifications and regulation of pluripotency in human stem cells
por: Wang, Yu-Chieh, et al.
Publicado: (2014)

Post-Translational Modifications of TRP Channels
por: Voolstra, Olaf, et al.
Publicado: (2014)

Post-translational modifications on the retinoblastoma protein
por: Zhou, Linbin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8ess9d1q2797e67vhmf0ofg34v