Transcriptomic Analysis of the Effect of Metformin against Cisplatin-Induced Ototoxicity: A Potential Mechanism of Metformin-Mediated Inhibition of Thioredoxin-Interacting Protein (Txnip) Gene Expression

Ototoxicity is the drug-induced damage of the inner ear, causing bilateral irreversible sensorineural hearing loss. Cisplatin is a widely used chemotherapeutic agent which causes ototoxicity as its side effect. Pretreatment with metformin prior to the application of cisplatin significantly decreased...

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Detalles Bibliográficos
Autores principales: Lee, Sehee, Choi, Sun, Park, Seok Hyun, Im, Gi Jung, Chang, Jiwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857533/
https://www.ncbi.nlm.nih.gov/pubmed/36661507
http://dx.doi.org/10.3390/cimb45010021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857533/
https://www.ncbi.nlm.nih.gov/pubmed/36661507
http://dx.doi.org/10.3390/cimb45010021

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