Inference of 3D genome architecture by modeling overdispersion of Hi-C data

MOTIVATION: We address the challenge of inferring a consensus 3D model of genome architecture from Hi-C data. Existing approaches most often rely on a two-step algorithm: first, convert the contact counts into distances, then optimize an objective function akin to multidimensional scaling (MDS) to i...

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Detalles Bibliográficos
Autores principales: Varoquaux, Nelle, Noble, William S, Vert, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857972/
https://www.ncbi.nlm.nih.gov/pubmed/36594573
http://dx.doi.org/10.1093/bioinformatics/btac838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857972/
https://www.ncbi.nlm.nih.gov/pubmed/36594573
http://dx.doi.org/10.1093/bioinformatics/btac838

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