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Inference of 3D genome architecture by modeling overdispersion of Hi-C data
MOTIVATION: We address the challenge of inferring a consensus 3D model of genome architecture from Hi-C data. Existing approaches most often rely on a two-step algorithm: first, convert the contact counts into distances, then optimize an objective function akin to multidimensional scaling (MDS) to i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857972/ https://www.ncbi.nlm.nih.gov/pubmed/36594573 http://dx.doi.org/10.1093/bioinformatics/btac838 |