The HIPK2/CDC14B-MeCP2 axis enhances the spindle assembly checkpoint block by promoting cyclin B translation

Mitotic perturbations activate the spindle assembly checkpoint (SAC) that keeps cells in prometaphase with high CDK1 activity. Prolonged mitotic arrest is eventually bypassed by gradual cyclin B decline followed by slippage of cells into G(1) without chromosome segregation, a process that promotes c...

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Detalles Bibliográficos
Autores principales: Partscht, Patrick, Simon, Alexander, Chen, Nan-Peng, Erhardt, Sylvia, Schiebel, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858502/
https://www.ncbi.nlm.nih.gov/pubmed/36662865
http://dx.doi.org/10.1126/sciadv.add6982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858502/
https://www.ncbi.nlm.nih.gov/pubmed/36662865
http://dx.doi.org/10.1126/sciadv.add6982

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