Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3Kα inhibitors

Inhibition of PI3K pathway has become a desirable strategy for cancer treatment. In this work, a series of 2, 6, 8-substituted Imidazo[1,2-a]pyridine derivatives were designed and screened for their activities against PI3Kα and a panel of PI3Kα-addicted cancer cells. Among them, compound 35 was iden...

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Detalles Bibliográficos
Autores principales: Chen, Rui, Wang, Zhongyuan, Sima, Lijie, Cheng, Hu, Luo, Bilan, Wang, Jianta, Guo, Bing, Mao, Shunyi, Zhou, Zhixu, Peng, Jingang, Tang, Lei, Liu, Xinfu, Liao, Weike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858543/
https://www.ncbi.nlm.nih.gov/pubmed/36650905
http://dx.doi.org/10.1080/14756366.2022.2155638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858543/
https://www.ncbi.nlm.nih.gov/pubmed/36650905
http://dx.doi.org/10.1080/14756366.2022.2155638

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