Cargando…

Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3Kα inhibitors

Inhibition of PI3K pathway has become a desirable strategy for cancer treatment. In this work, a series of 2, 6, 8-substituted Imidazo[1,2-a]pyridine derivatives were designed and screened for their activities against PI3Kα and a panel of PI3Kα-addicted cancer cells. Among them, compound 35 was iden...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Rui, Wang, Zhongyuan, Sima, Lijie, Cheng, Hu, Luo, Bilan, Wang, Jianta, Guo, Bing, Mao, Shunyi, Zhou, Zhixu, Peng, Jingang, Tang, Lei, Liu, Xinfu, Liao, Weike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858543/ https://www.ncbi.nlm.nih.gov/pubmed/36650905 http://dx.doi.org/10.1080/14756366.2022.2155638

Ejemplares similares

Substituted imidazopyridines as potent inhibitors of HCV replication()
por: Vliegen, Inge, et al.
Publicado: (2009)

Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs
por: Dabiri, Yasamin, et al.
Publicado: (2019)

Recent Developments in the Photochemical Synthesis of Functionalized Imidazopyridines
por: Tran, Christine, et al.
Publicado: (2022)

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines
por: Large, Jonathan M., et al.
Publicado: (2019)

Toward more potent imidazopyridine inhibitors of Candida albicans Bdf1: Modeling the role of structural waters in selective ligand binding
por: Zhou, Yingsheng, et al.
Publicado: (2022)

Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels
por: O'Malley, Theresa, et al.
Publicado: (2018)

Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues
por: Papadakis, Georgios, et al.
Publicado: (2020)

Electrochemical Dehydrogenative C−H Aminomethylation of Imidazopyridines and Related Heterocycles
por: Huang, Raolin, et al.
Publicado: (2022)

Structure–Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis
por: Dichiara, Maria, et al.
Publicado: (2023)

A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A(2)
por: Anilkumar, Nirvanappa C., et al.
Publicado: (2015)

Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1
por: Su, Jung-Chen, et al.
Publicado: (2018)

Recent advances on the transition-metal-catalyzed synthesis of imidazopyridines: an updated coverage
por: Reen, Gagandeep Kour, et al.
Publicado: (2019)

Iodine-Catalyzed Multicomponent Synthesis of Highly Fluorescent Pyrimidine-Linked Imidazopyridines
por: Acharya, Swadhin Swaraj, et al.
Publicado: (2022)

Regioselective C3–H Alkylation of Imidazopyridines with Donor–Acceptor Cyclopropanes
por: Dalkilic, Oguzhan, et al.
Publicado: (2023)

Theoretical and Anti-Klebsiella pneumoniae Evaluations of Substituted 2,7-dimethylimidazo[1,2-a]pyridine-3-carboxamide and Imidazopyridine Hydrazide Derivatives
por: Mali, Suraj N., et al.
Publicado: (2023)

Discovery of Novel Imidazopyridine GSK-3β Inhibitors Supported by Computational Approaches
por: Buonfiglio, Rosa, et al.
Publicado: (2020)

A Novel Imidazopyridine Derivative Exerts Anticancer Activity by Inducing Mitochondrial Pathway-Mediated Apoptosis
por: Wang, Juanli, et al.
Publicado: (2020)

An Investigation of Molecular Docking and Molecular Dynamic Simulation on Imidazopyridines as B-Raf Kinase Inhibitors
por: Xie, Huiding, et al.
Publicado: (2015)

Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors
por: Kang, Seok Jong, et al.
Publicado: (2020)

Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists
por: Butera, Roberto, et al.
Publicado: (2021)

Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies
por: Attram, Henrietta D., et al.
Publicado: (2023)

Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
por: Pan, Mengwu, et al.
Publicado: (2023)

A Novel Imidazopyridine Derivative Exhibits Anticancer Activity in Breast Cancer by Inhibiting Wnt/β‑catenin Signaling
por: He, Liu-Jun, et al.
Publicado: (2020)

Novel Imidazopyridine Derivatives Possess Anti-Tumor Effect on Human Castration-Resistant Prostate Cancer Cells
por: Ingersoll, Matthew A., et al.
Publicado: (2015)

Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity
por: Qian, Yuanyuan, et al.
Publicado: (2016)

Imidazopyridine-fused [1,3]diazepinones: modulations of positions 2 to 4 and their impacts on the anti-melanoma activity
por: Baccon-Sollier, Paul Le, et al.
Publicado: (2020)

Synthesis and Structure−Activity Relationships of Imidazopyridine/Pyrimidine‐ and Furopyridine‐Based Anti‐infective Agents against Trypanosomiases
por: Silva, Daniel G., et al.
Publicado: (2020)

Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking
por: Elseginy, Samia A., et al.
Publicado: (2022)

Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances
por: Liu, Xiaochuan, et al.
Publicado: (2016)

Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses
por: Tobo, Ayaka, et al.
Publicado: (2015)

A Combined Pharmacophore Modeling, 3D QSAR and Virtual Screening Studies on Imidazopyridines as B-Raf Inhibitors
por: Xie, Huiding, et al.
Publicado: (2015)

Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review
por: Sanapalli, Bharat Kumar Reddy, et al.
Publicado: (2022)

De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells
por: Ravish, Akshay, et al.
Publicado: (2023)

Imidazopyridine Amides: Synthesis, Mycobacterium smegmatis CIII(2)CIV(2) Supercomplex Binding, and In Vitro Antimycobacterial Activity
por: Abdelaziz, Rana, et al.
Publicado: (2023)

Imidazopyridine-Based Thiazole Derivatives as Potential Antidiabetic Agents: Synthesis, In Vitro Bioactivity, and In Silico Molecular Modeling Approach
por: Hussain, Rafaqat, et al.
Publicado: (2023)

New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound
por: Yang, Xiuyan, et al.
Publicado: (2017)

A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA
por: Schaenzer, Adam J., et al.
Publicado: (2017)

A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma
por: Zhu, Jingyu, et al.
Publicado: (2014)

Selection Study for B+- -> (K-+ pi+- pi-+ pi+-)D K+- and B+- -> (K+ K- pi+ pi-)D K+-".
por: Hunt, P, et al.
Publicado: (2009)

Correction: A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma
por: Zhu, Jingyu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_avnod4e9p8o30qgn0a48jauhn2