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Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2(G112+5X) Mutation in a Guinea Pig Ventricular Myocyte Computational Model
Calsequestrin Type 2 (CASQ2) is a high-capacity, low-affinity, Ca(2+)-binding protein expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 have been linked to the arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT2) that occurs with acute emotio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858930/ https://www.ncbi.nlm.nih.gov/pubmed/36672764 http://dx.doi.org/10.3390/genes14010023 |