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Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2(G112+5X) Mutation in a Guinea Pig Ventricular Myocyte Computational Model

Calsequestrin Type 2 (CASQ2) is a high-capacity, low-affinity, Ca(2+)-binding protein expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 have been linked to the arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT2) that occurs with acute emotio...

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Detalles Bibliográficos
Autores principales:	Paudel, Roshan, Jafri, Mohsin Saleet, Ullah, Aman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858930/ https://www.ncbi.nlm.nih.gov/pubmed/36672764 http://dx.doi.org/10.3390/genes14010023

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