The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response

The functioning of the eukaryotic cell genome is mediated by sophisticated protein-nucleic-acid complexes, whose minimal structural unit is the nucleosome. After the damage to genomic DNA, repair proteins need to gain access directly to the lesion; therefore, the initiation of the DNA damage respons...

Descripción completa

Detalles Bibliográficos
Autores principales: Belousova, Ekaterina A., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859207/
https://www.ncbi.nlm.nih.gov/pubmed/36672853
http://dx.doi.org/10.3390/genes14010112
_version_ 1784874297491193856
author Belousova, Ekaterina A.
Lavrik, Olga I.
author_facet Belousova, Ekaterina A.
Lavrik, Olga I.
author_sort Belousova, Ekaterina A.
collection PubMed
description The functioning of the eukaryotic cell genome is mediated by sophisticated protein-nucleic-acid complexes, whose minimal structural unit is the nucleosome. After the damage to genomic DNA, repair proteins need to gain access directly to the lesion; therefore, the initiation of the DNA damage response inevitably leads to local chromatin reorganisation. This review focuses on the possible involvement of PARP1, as well as proteins acting nucleosome compaction, linker histone H1 and non-histone chromatin protein HMGB1. The polymer of ADP-ribose is considered the main regulator during the development of the DNA damage response and in the course of assembly of the correct repair complex.
format Online
Article
Text
id pubmed-9859207
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98592072023-01-21 The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response Belousova, Ekaterina A. Lavrik, Olga I. Genes (Basel) Review The functioning of the eukaryotic cell genome is mediated by sophisticated protein-nucleic-acid complexes, whose minimal structural unit is the nucleosome. After the damage to genomic DNA, repair proteins need to gain access directly to the lesion; therefore, the initiation of the DNA damage response inevitably leads to local chromatin reorganisation. This review focuses on the possible involvement of PARP1, as well as proteins acting nucleosome compaction, linker histone H1 and non-histone chromatin protein HMGB1. The polymer of ADP-ribose is considered the main regulator during the development of the DNA damage response and in the course of assembly of the correct repair complex. MDPI 2022-12-30 /pmc/articles/PMC9859207/ /pubmed/36672853 http://dx.doi.org/10.3390/genes14010112 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Belousova, Ekaterina A.
Lavrik, Olga I.
The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response
title The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response
title_full The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response
title_fullStr The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response
title_full_unstemmed The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response
title_short The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response
title_sort role of parp1 and par in atp-independent nucleosome reorganisation during the dna damage response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859207/
https://www.ncbi.nlm.nih.gov/pubmed/36672853
http://dx.doi.org/10.3390/genes14010112
work_keys_str_mv AT belousovaekaterinaa theroleofparp1andparinatpindependentnucleosomereorganisationduringthednadamageresponse
AT lavrikolgai theroleofparp1andparinatpindependentnucleosomereorganisationduringthednadamageresponse
AT belousovaekaterinaa roleofparp1andparinatpindependentnucleosomereorganisationduringthednadamageresponse
AT lavrikolgai roleofparp1andparinatpindependentnucleosomereorganisationduringthednadamageresponse

Ejemplares similares