Targeting RAS mutants in malignancies: successes, failures, and reasons for hope

RAS genes are the most frequently mutated oncogenes and play critical roles in the development and progression of malignancies. The mutation, isoform (KRAS, HRAS, and NRAS), position, and type of substitution vary depending on the tissue types. Despite decades of developing RAS‐targeted therapies, o...

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Detalles Bibliográficos
Autores principales: Yang, Hang, Zhou, Xinyi, Fu, Dongliang, Le, Chenqin, Wang, Jiafeng, Zhou, Quan, Liu, Xiangrui, Yuan, Ying, Ding, Kefeng, Xiao, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859734/
https://www.ncbi.nlm.nih.gov/pubmed/36316602
http://dx.doi.org/10.1002/cac2.12377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859734/
https://www.ncbi.nlm.nih.gov/pubmed/36316602
http://dx.doi.org/10.1002/cac2.12377

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