Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends

Growing microtubule ends organize end-tracking proteins into comets of mixed composition. Here using a reconstituted fission yeast system consisting of end-binding protein Mal3, kinesin Tea2 and cargo Tip1, we found that these proteins can be driven into liquid-phase droplets both in solution and at...

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Detalles Bibliográficos
Autores principales: Maan, Renu, Reese, Louis, Volkov, Vladimir A., King, Matthew R., van der Sluis, Eli O., Andrea, Nemo, Evers, Wiel H., Jakobi, Arjen J., Dogterom, Marileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859754/
https://www.ncbi.nlm.nih.gov/pubmed/36536175
http://dx.doi.org/10.1038/s41556-022-01037-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859754/
https://www.ncbi.nlm.nih.gov/pubmed/36536175
http://dx.doi.org/10.1038/s41556-022-01037-0

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