OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis

RIPK3–ZBP1–MLKL-mediated necroptosis is a proinflammatory cell death process that is crucial for antiviral host defence. RIPK3 self-oligomerization and autophosphorylation are prerequisites for executing necroptosis, yet the underlying mechanism of virus-induced RIPK3 activation remains elusive. Int...

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Detalles Bibliográficos
Autores principales: Lee, Shin-Ae, Chang, Lin-Chun, Jung, WooRam, Bowman, James W., Kim, Dokyun, Chen, Weiqiang, Foo, Suan-Sin, Choi, Youn Jung, Choi, Un Yung, Bowling, Anna, Yoo, Ji-Seung, Jung, Jae U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859756/
https://www.ncbi.nlm.nih.gov/pubmed/36604592
http://dx.doi.org/10.1038/s41556-022-01039-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859756/
https://www.ncbi.nlm.nih.gov/pubmed/36604592
http://dx.doi.org/10.1038/s41556-022-01039-y

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