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OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis
RIPK3–ZBP1–MLKL-mediated necroptosis is a proinflammatory cell death process that is crucial for antiviral host defence. RIPK3 self-oligomerization and autophosphorylation are prerequisites for executing necroptosis, yet the underlying mechanism of virus-induced RIPK3 activation remains elusive. Int...
Autores principales: | Lee, Shin-Ae, Chang, Lin-Chun, Jung, WooRam, Bowman, James W., Kim, Dokyun, Chen, Weiqiang, Foo, Suan-Sin, Choi, Youn Jung, Choi, Un Yung, Bowling, Anna, Yoo, Ji-Seung, Jung, Jae U. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859756/ https://www.ncbi.nlm.nih.gov/pubmed/36604592 http://dx.doi.org/10.1038/s41556-022-01039-y |
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