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Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation
Cardiac muscle contraction is regulated by Ca(2+)-induced structural changes of the thin filaments to permit myosin cross-bridge cycling driven by ATP hydrolysis in the sarcomere. In congestive heart failure, contraction is weakened, and thus targeting the contractile proteins of the sarcomere is a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859762/ https://www.ncbi.nlm.nih.gov/pubmed/36633587 http://dx.doi.org/10.1085/jgp.202113054 |