Sarcomere length affects Ca(2+) sensitivity of contraction in ischemic but not non-ischemic myocardium

In healthy hearts, myofilaments become more sensitive to Ca(2+) as the myocardium is stretched. This effect is known as length-dependent activation and is an important cellular-level component of the Frank–Starling mechanism. Few studies have measured length-dependent activation in the myocardium fr...

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Detalles Bibliográficos
Autores principales: Tanner, Bertrand C.W., Awinda, Peter O., Agonias, Keinan B., Attili, Seetharamaiah, Blair, Cheavar A., Thompson, Mindy S., Walker, Lori A., Kampourakis, Thomas, Campbell, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859763/
https://www.ncbi.nlm.nih.gov/pubmed/36633584
http://dx.doi.org/10.1085/jgp.202213200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859763/
https://www.ncbi.nlm.nih.gov/pubmed/36633584
http://dx.doi.org/10.1085/jgp.202213200

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