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Sarcomere length affects Ca(2+) sensitivity of contraction in ischemic but not non-ischemic myocardium
In healthy hearts, myofilaments become more sensitive to Ca(2+) as the myocardium is stretched. This effect is known as length-dependent activation and is an important cellular-level component of the Frank–Starling mechanism. Few studies have measured length-dependent activation in the myocardium fr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859763/ https://www.ncbi.nlm.nih.gov/pubmed/36633584 http://dx.doi.org/10.1085/jgp.202213200 |