Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation

Accumulating evidence suggests that glutathione loss is closely associated with the progression of neurodegenerative disorders. Here, we found that the neuronal conditional-knockout (KO) of glutamyl-cysteine-ligase catalytic-subunit (GCLC), a rate-limiting enzyme for glutathione synthesis, induced b...

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Detalles Bibliográficos
Autores principales: Hashimoto, Shoko, Matsuba, Yukio, Takahashi, Mika, Kamano, Naoko, Watamura, Naoto, Sasaguri, Hiroki, Takado, Yuhei, Yoshihara, Yoshihiro, Saito, Takashi, Saido, Takaomi C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859798/
https://www.ncbi.nlm.nih.gov/pubmed/36670138
http://dx.doi.org/10.1038/s41598-023-27653-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859798/
https://www.ncbi.nlm.nih.gov/pubmed/36670138
http://dx.doi.org/10.1038/s41598-023-27653-w

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